Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.47 |
| ▸ | JAK1 | P23458 | 15/20 | 0.47 |
| ▸ | JAK2 | O60674 | 11/20 | 0.47 |
| ▸ | TYK2 | P29597 | 6/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359056 | 1.00 | JAK3 (0.47) | JAK3JAK1JAK2TYK2BTK | |
| SCHEMBL28359207 | 0.93 | JAK3 (0.47) | JAK3JAK1JAK2TYK2BTK | |
| SCHEMBL28359221 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2PIM1 | |
| SCHEMBL28359023 | 0.79 | JAK2 (0.46) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL29552433 | 0.79 | JAK2 (0.46) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL28359013 | 0.78 | JAK2 (0.42) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29551990 | 0.78 | JAK2 (0.42) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29922874 | 0.76 | JAK2 (0.40) | JAK3JAK1JAK2TYK2RORC | |
| SCHEMBL28359015 | 0.76 | TYK2 (0.44) | JAK3JAK1JAK2TYK2RORC | |
| SCHEMBL29922729 | 0.76 | TYK2 (0.44) | JAK3JAK1JAK2TYK2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |