SCHEMBL29924747

SCHEMBL29924747

CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O)c(F)c1)C1CC1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.42
KDM1A O60341 3/20 0.41
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HSD11B1 P28845 1/20 0.41
EPHX2 P34913 1/20 0.40
HTR2A P28223 3/20 0.40
CETP P11597 2/20 0.39
STAT3 P40763 1/20 0.39
RXRA P19793 2/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
CXCR3 P49682 1/20 0.38
HDAC3 O15379 1/20 0.37
LTA4H P09960 1/20 0.36
LPAR1 Q92633 1/20 0.36
LPAR5 Q9H1C0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24619710 1.00 NR1H4 (0.42) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL24619382 0.86 KDM1A (0.43) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL29925353 0.86 KDM1A (0.43) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL29924818 0.84 NR1H4 (0.43) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL24619470 0.81 HDAC8 (0.48) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL29925049 0.80 NR1H4 (0.42) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL1074688 0.79 HDAC8 (0.41) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL7489022 0.79 SLC6A4 (0.46) HTR2A
SCHEMBL24619373 0.79 BACE1 (0.40) NR1H4KDM1AHDAC8HDAC6HSD11B1
SCHEMBL29924710 0.79 BACE1 (0.40) NR1H4KDM1AHDAC8HDAC6HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4274569-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2023-11-15 EP disclosed
CN-116635028-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2023-08-22 CN disclosed
WO-2022150316-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-07-14 WO disclosed