Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14926013 | 0.85 | BRD4 (0.46) | NAMPTBRD4KITWNT3A | |
| SCHEMBL30512305 | 0.85 | BRD4 (0.46) | NAMPTBRD4KITWNT3A | |
| SCHEMBL14912248 | 0.85 | NAMPT (0.42) | NAMPTBTK | |
| SCHEMBL29741933 | 0.81 | BTK (0.42) | BTKWNT3A | |
| SCHEMBL29742005 | 0.79 | BTK (0.40) | BTKHRH2HRH1 | |
| SCHEMBL29742086 | 0.78 | BTK (0.39) | BTKHRH2HRH1 | |
| SCHEMBL29742153 | 0.77 | BTK (0.37) | BTK | |
| SCHEMBL29742089 | 0.77 | SMN1; SMN2 (0.36) | HRH2HRH1 | |
| SCHEMBL14914480 | 0.74 | BTK (0.54) | BTK | |
| SCHEMBL29741962 | 0.74 | BTK (0.54) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4050012-A1 | PYRIDONE BORONATES FOR THE PREPARATION OF INHIBITORS OF BTK ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2022-08-31 | — | — | EP | disclosed |