Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29925747 | 1.00 | PIM1 (0.38) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL27031746 | 1.00 | PIM1 (0.38) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL27031805 | 1.00 | PIM1 (0.38) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL27031824 | 1.00 | PIM1 (0.38) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL29925683 | 1.00 | PIM1 (0.38) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL31023367 | 0.89 | AXL (0.41) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL29925800 | 0.89 | AXL (0.41) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL29925849 | 0.84 | GSK3B (0.39) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL29925496 | 0.84 | GSK3B (0.39) | PIM1GSK3BPIM3PIM2LRRK2 | |
| SCHEMBL27031742 | 0.84 | GSK3B (0.39) | PIM1GSK3BPIM3PIM2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | claimed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | claimed |
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |