Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 18/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 18/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 18/20 | 1.00 |
| ▸ | CDK2 | P24941 | 18/20 | 1.00 |
| ▸ | CDK4 | P11802 | 14/20 | 1.00 |
| ▸ | CCND1 | P24385 | 14/20 | 1.00 |
| ▸ | CCND3 | P30281 | 14/20 | 1.00 |
| ▸ | CDK6 | Q00534 | 14/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 8/20 | 1.00 |
| ▸ | CDK7 | P50613 | 8/20 | 1.00 |
| ▸ | CDK9 | P50750 | 8/20 | 1.00 |
| ▸ | CCNH | P51946 | 8/20 | 1.00 |
| ▸ | MNAT1 | P51948 | 8/20 | 1.00 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900928 | 1.00 | CDK1 (1.00) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22900945 | 0.87 | CDK1 (0.79) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22901122 | 0.86 | CDK2 (0.84) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL29926459 | 0.86 | CDK2 (0.84) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22901217 | 0.86 | CCNE1 (1.00) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22901019 | 0.85 | CCNE1 (0.74) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL29926319 | 0.85 | CCNE1 (0.74) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22900933 | 0.85 | CCNE1 (0.73) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22901040 | 0.85 | CCNE1 (0.73) | CDK1CCNB1CCNE1CDK2CDK4 | |
| SCHEMBL22901267 | 0.85 | CCNE1 (0.73) | CDK1CCNB1CCNE1CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11472791-B2 | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors | INCYTE CORPORATION (US) | 2022-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11472791-B2 | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors | CDK2, CDK2AP2, CDK4 | CDK1 6/4885CCNB1 44/4885CCNE1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.