Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.58 |
| ▸ | AR | P10275 | 4/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.51 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132100 | 1.00 | CRBN (0.58) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL20234891 | 0.99 | CRBN (0.58) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL29802963 | 0.99 | CRBN (0.58) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL29927733 | 0.98 | CRBN (0.59) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL29132140 | 0.98 | CRBN (0.59) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL29132119 | 0.97 | CRBN (0.55) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL23860203 | 0.96 | CRBN (0.56) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL30144161 | 0.96 | CRBN (0.56) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL29132182 | 0.96 | CRBN (0.58) | CRBNARDDB1IRAK1IRAK4 | |
| SCHEMBL20231763 | 0.96 | CRBN (0.59) | CRBNARDDB1IRAK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |