Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29928016 | 0.85 | SMN1; SMN2 (0.46) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30963412 | 0.82 | SMN1; SMN2 (0.64) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL30720934 | 0.79 | SMN1; SMN2 (0.45) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29927705 | 0.79 | SMN1; SMN2 (0.45) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31540024 | 0.78 | SMN1; SMN2 (0.50) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL27302851 | 0.78 | SMN1; SMN2 (0.55) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30484110 | 0.78 | MEN1 (0.57) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27163021 | 0.77 | SMN1; SMN2 (0.46) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12526670 | 0.77 | SMN1; SMN2 (0.60) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL871462 | 0.77 | SMN1; SMN2 (0.60) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |