Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.80 |
| ▸ | FLT3 | P36888 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994495 | 1.00 | AXL (0.80) | AXLFLT3KDRINSRHRH4 | |
| SCHEMBL29928998 | 0.89 | AXL (1.00) | AXLFLT3KITTTKSLC2A1 | |
| SCHEMBL4253962 | 0.89 | AXL (1.00) | AXLFLT3KITTTKSLC2A1 | |
| SCHEMBL3953555 | 0.88 | AXL (0.73) | AXLFLT3KDRINSRKIT | |
| SCHEMBL4987947 | 0.87 | AXL (0.62) | AXLFLT3KDRINSRHRH4 | |
| SCHEMBL29928096 | 0.85 | AXL (0.62) | AXLFLT3KDRINSRHRH4 | |
| SCHEMBL4995010 | 0.85 | AXL (0.62) | AXLFLT3KDRINSRHRH4 | |
| SCHEMBL4236700 | 0.85 | AXL (0.59) | AXLFLT3KDRINSRHRH4 | |
| SCHEMBL4242293 | 0.85 | AXL (0.73) | AXLFLT3KDRINSRKIT | |
| SCHEMBL30373558 | 0.85 | AXL (0.73) | AXLFLT3KDRINSRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |