Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.77 |
| ▸ | KDR | P35968 | 7/20 | 0.77 |
| ▸ | INSR | P06213 | 6/20 | 0.77 |
| ▸ | FLT3 | P36888 | 6/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4236664 | 1.00 | AXL (0.77) | AXLKDRINSRFLT3KIT | |
| SCHEMBL4997718 | 0.87 | AXL (1.00) | AXLKDRINSRFLT3KIT | |
| SCHEMBL29928442 | 0.84 | FLT3 (0.69) | AXLKDRINSRFLT3KIT | |
| SCHEMBL4986533 | 0.84 | FLT3 (0.69) | AXLKDRINSRFLT3KIT | |
| SCHEMBL3963556 | 0.83 | AXL (0.89) | AXLKDRINSRFLT3KIT | |
| SCHEMBL29928415 | 0.83 | AXL (0.89) | AXLKDRINSRFLT3KIT | |
| SCHEMBL4235789 | 0.79 | BACE1 (0.66) | AXLINSR | |
| SCHEMBL29928116 | 0.79 | BACE1 (0.66) | AXLINSR | |
| SCHEMBL3959517 | 0.79 | AXL (0.62) | AXLKDRINSRFLT3KIT | |
| SCHEMBL29929865 | 0.77 | AXL (1.00) | AXLKDRINSRFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |