Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 15/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | IL1B | P01584 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25133246 | 1.00 | IKZF2 (0.51) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL29928084 | 0.93 | IKZF2 (0.51) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL25133272 | 0.93 | IKZF2 (0.51) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL27028400 | 0.88 | IKZF2 (0.50) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL25133813 | 0.88 | IKZF2 (0.49) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL20234882 | 0.86 | CRBN (0.55) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL29927677 | 0.86 | CRBN (0.55) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL27272299 | 0.86 | IKZF2 (0.52) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL25134274 | 0.85 | IKZF2 (0.52) | IKZF2CRBNIKZF3DDB1ADRA1D | |
| SCHEMBL29927455 | 0.85 | IKZF2 (0.52) | IKZF2CRBNIKZF3DDB1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |