Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 7/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25133245 | 1.00 | IKZF2 (0.50) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL29132310 | 1.00 | IKZF2 (0.50) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL29927969 | 0.97 | IKZF2 (0.48) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL24718660 | 0.97 | IKZF2 (0.48) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL25133961 | 0.94 | IKZF2 (0.46) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL25134267 | 0.94 | IKZF2 (0.47) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL29132244 | 0.94 | IKZF2 (0.47) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL29927571 | 0.94 | IKZF2 (0.47) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL26609638 | 0.93 | CRBN (0.51) | IKZF2CRBNIKZF3IKZF1DDB1 | |
| SCHEMBL20231914 | 0.93 | CRBN (0.53) | IKZF2CRBNIKZF3IKZF1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |