Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.63 |
| ▸ | KDR | P35968 | 6/20 | 0.63 |
| ▸ | INSR | P06213 | 6/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960026 | 1.00 | AXL (0.63) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL3958288 | 0.88 | AXL (0.80) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL29928559 | 0.88 | AXL (0.80) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL3960718 | 0.88 | AXL (0.66) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL4993005 | 0.82 | AXL (0.76) | AXLKDRINSRFLT3 | |
| SCHEMBL29929755 | 0.81 | AXL (0.73) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL3959507 | 0.81 | AXL (0.73) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL4254711 | 0.80 | AXL (0.85) | AXLKDRINSR | |
| SCHEMBL4238608 | 0.79 | AXL (0.79) | AXLKDRINSRACHEBACE1 | |
| SCHEMBL29927936 | 0.79 | AXL (0.79) | AXLKDRINSRACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |