Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 6/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27240951 | 1.00 | MAP4K1 (0.40) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL26977031 | 1.00 | MAP4K1 (0.40) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL26977428 | 0.86 | JAK3 (0.46) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL29929221 | 0.86 | JAK3 (0.46) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL27241016 | 0.86 | CCNT1 (0.39) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL26977291 | 0.86 | CCNT1 (0.39) | MAP4K1JAK1JAK3TYK2AURKA | |
| SCHEMBL29113541 | 0.86 | JAK3 (0.40) | JAK1JAK3TYK2AURKAAURKB | |
| SCHEMBL29113572 | 0.85 | JAK3 (0.38) | JAK1JAK3TYK2AURKAAURKB | |
| SCHEMBL29113539 | 0.85 | JAK3 (0.38) | JAK1JAK3TYK2AURKAAURKB | |
| SCHEMBL30931275 | 0.84 | JAK3 (0.48) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |