Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 12/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22129386 | 1.00 | SMO (0.45) | SMOPROKR1CNR2PIM1PIM3 | |
| SCHEMBL28421081 | 0.85 | CNR2 (0.42) | SMOCNR2 | |
| SCHEMBL22129420 | 0.78 | SMO (0.39) | SMO | |
| SCHEMBL29404134 | 0.77 | SMO (0.42) | SMOCNR2 | |
| SCHEMBL22129464 | 0.77 | SMO (0.41) | SMO | |
| SCHEMBL22153061 | 0.76 | PDE9A (0.41) | SMOPDE9A | |
| SCHEMBL28422543 | 0.75 | PROKR1 (0.38) | SMOPROKR1TYK2LRRK2PDE9A | |
| SCHEMBL12524364 | 0.72 | CHRM4 (0.39) | CNR2KCNH2MCHR1TYK2 | |
| SCHEMBL30937175 | 0.70 | PDE10A (0.50) | PROKR1CNR2 | |
| SCHEMBL11981511 | 0.70 | EGLN2 (0.40) | PROKR1KCNH2TYK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111333626-B | Phenyl pyrrolidine compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-18 | — | — | CN | disclosed |