Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 16/20 | 0.72 |
| ▸ | KIT | P10721 | 11/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 2/20 | 0.64 |
| ▸ | AXL | P30530 | 4/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955894 | 1.00 | FLT3 (0.72) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4037878 | 0.86 | FLT3 (0.73) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4039004 | 0.85 | FLT3 (0.69) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4039203 | 0.84 | FLT3 (0.73) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4046870 | 0.84 | FLT3 (1.00) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4040331 | 0.82 | FLT3 (0.65) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4041779 | 0.82 | FLT3 (0.72) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4044746 | 0.81 | FLT3 (0.67) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4041751 | 0.81 | FLT3 (0.72) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4041560 | 0.81 | FLT3 (0.60) | FLT3KITIRAK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |