Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pf-03758309. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 known ✓ | O96013 | 19/20 | 0.99 |
| ▸ | CDK7 | P50613 | 2/20 | 0.99 |
| ▸ | CCNH | P51946 | 2/20 | 0.99 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.99 |
| ▸ | PLK4 | O00444 | 1/20 | 0.99 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.99 |
| ▸ | AURKA | O14965 | 1/20 | 0.99 |
| ▸ | GAK | O14976 | 1/20 | 0.99 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.99 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.99 |
| ▸ | STK16 | O75716 | 1/20 | 0.99 |
| ▸ | PAK3 | O75914 | 1/20 | 0.99 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.99 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.99 |
| ▸ | LATS1 | O95835 | 1/20 | 0.99 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.99 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.99 |
| ▸ | TP53 | P04637 | 1/20 | 0.99 |
| ▸ | PRKCG | P05129 | 1/20 | 0.99 |
| ▸ | PRKCB | P05771 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-03758309 SCHEMBL16101450 | 0.99 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| Pf-03758309 SCHEMBL1369342 | 0.99 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL1369035 | 0.91 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL24513386 | 0.89 | PAK4 (0.81) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL1369668 | 0.88 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL1942571 | 0.88 | PAK4 (0.80) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL1942859 | 0.86 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL1942862 | 0.86 | PAK4 (1.00) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL22164724 | 0.83 | PAK4 (0.72) | PAK4CDK7CCNHMNAT1PLK4 | |
| SCHEMBL22164721 | 0.83 | PAK4 (0.72) | PAK4CDK7CCNHMNAT1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115927524-A | Preparation process of compound composition of multiple traditional Chinese medicine active components for treating tumors | 麒麟(山东)医药科技有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-116287093-A | Screening method of cell-embedded death agonist or antagonist and application thereof | 无量光生物科技(鹤山市)有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115927524-A | Preparation process of compound composition of multiple traditional Chinese medicine active components for treating tumors | 麒麟(山东)医药科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| US-20230079757-A1 | METHODS AND MATERIALS FOR TREATING CANCER | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2023-03-16 | — | — | US | disclosed |
| EP-4107278-A1 | METHODS AND MATERIALS FOR TREATING CANCER | Mayo Foundation for Medical Education and Research (US) | 2022-12-28 | — | — | EP | disclosed |
| CN-115192582-A | Application of PAK4 inhibitor in preparation of drugs for targeted inhibition of STAT3 and NF kappa B signal pathways | 麒麟(山东)医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |