Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23364831 | 1.00 | IRAK4 (0.41) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL23380055 | 0.84 | IRAK4 (0.41) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL16921588 | 0.82 | CA12 (0.52) | ALDH1A1KDM4ELMNACA1CA2 | |
| SCHEMBL23364836 | 0.80 | CA1 (0.48) | IRAK4ALDH1A1ACHEKDM4ETDP1 | |
| SCHEMBL23364568 | 0.80 | IRAK4 (0.46) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL29932864 | 0.80 | IRAK4 (0.46) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL5725592 | 0.79 | GSK3B (0.48) | ALDH1A1KDM4ETDP1LMNAGSK3B | |
| SCHEMBL28020118 | 0.78 | CA12 (0.53) | IRAK4ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL23364634 | 0.78 | CA1 (0.56) | IRAK4ALDH1A1ACHEKDM4ETDP1 | |
| SCHEMBL11442930 | 0.76 | IRAK4 (0.62) | IRAK4IDO1TDO2ALDH1A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058439-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | Genzyme Corporation (US) | 2022-09-21 | — | — | EP | disclosed |
| CN-115003659-A | 5-membered heteroaryl amino sulfonamides for the treatment of conditions mediated by a deficiency in CFTR activity | 健赞公司 | 2022-09-02 | — | — | CN | disclosed |