Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231342 | 0.85 | ACKR3 (0.69) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL12121026 | 0.84 | HTT (0.74) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL31203044 | 0.84 | SMN1; SMN2 (0.74) | HTTSMN1; SMN2CYP1A2RAD52CHEK2 | |
| SCHEMBL14547928 | 0.84 | POLB (0.51) | HTTALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL2993558 | 0.83 | HTT (0.57) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL14094449 | 0.83 | CYP1A2 (0.59) | HTTSMN1; SMN2CYP1A2RAD52CHEK2 | |
| SCHEMBL2926409 | 0.83 | CYP1A2 (0.67) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL20568584 | 0.82 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL13575515 | 0.81 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2ACKR3CYP1A2RAD52 | |
| SCHEMBL6108941 | 0.81 | MCHR1 (0.57) | HTTSMN1; SMN2CYP1A2RAD52ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | claimed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTT 2728/4885SMN1; SMN2 3033/4885ACKR3 324/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTT 2728/4885SMN1; SMN2 3033/4885ACKR3 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.