Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210330 | 1.00 | JAK3 (0.42) | JAK3IDO1TDO2CCNT1CDK9 | |
| SCHEMBL29936435 | 1.00 | JAK3 (0.42) | JAK3IDO1TDO2CCNT1CDK9 | |
| SCHEMBL18210055 | 1.00 | JAK3 (0.42) | JAK3IDO1TDO2CCNT1CDK9 | |
| SCHEMBL22191901 | 0.92 | JAK3 (0.42) | JAK3IDO1TDO2CCNT1CDK9 | |
| SCHEMBL20617457 | 0.92 | JAK3 (0.42) | JAK3IDO1TDO2CCNT1CDK9 | |
| SCHEMBL29936551 | 0.89 | ALOX5AP (0.36) | JAK3PIK3CDKDM4EMEN1ALDH1A1 | |
| SCHEMBL29936498 | 0.89 | ALOX5AP (0.36) | JAK3PIK3CDKDM4EMEN1ALDH1A1 | |
| SCHEMBL18210421 | 0.89 | ALOX5AP (0.36) | JAK3PIK3CDKDM4EMEN1ALDH1A1 | |
| SCHEMBL18210156 | 0.89 | ALOX5AP (0.36) | JAK3PIK3CDKDM4EMEN1ALDH1A1 | |
| SCHEMBL18210163 | 0.87 | JAK3 (0.41) | JAK3PIK3CDKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288943-B1 | PYRROLO[2,3-B]PYRAZINYL ACRYLAMIDES AND EPOXIDES THEREOF AS INHIBITORS OF JANUS KINASE | PFIZER (US) | 2022-09-28 | — | — | EP | disclosed |