Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240363 | 1.00 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL24179626 | 1.00 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL384788 | 1.00 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL29936064 | 1.00 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL16903405 | 0.92 | PREP (0.54) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL24837479 | 0.90 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL23553450 | 0.88 | GRIN2B (0.47) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL28411733 | 0.88 | HTR2C (0.59) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL25841627 | 0.88 | HTR2C (0.59) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL23196743 | 0.86 | POLB (0.56) | HTR2CPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288943-B1 | PYRROLO[2,3-B]PYRAZINYL ACRYLAMIDES AND EPOXIDES THEREOF AS INHIBITORS OF JANUS KINASE | PFIZER (US) | 2022-09-28 | — | — | EP | disclosed |