Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP3 | Q9NSD7 | 18/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27001833 | 1.00 | RXFP3 (1.00) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL27001810 | 0.94 | RXFP3 (0.91) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL29936647 | 0.94 | RXFP3 (1.00) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL27001795 | 0.94 | RXFP3 (1.00) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL29937054 | 0.94 | RXFP3 (0.91) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL27001826 | 0.93 | RXFP3 (1.00) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL29936644 | 0.93 | RXFP3 (1.00) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL27001823 | 0.93 | RXFP3 (0.92) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL29937004 | 0.93 | RXFP3 (0.92) | RXFP3TMEM97ALDH1A1NPC1LMNA | |
| SCHEMBL29936606 | 0.92 | RXFP3 (0.88) | RXFP3TMEM97ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304630-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | Research Triangle Institute (US) | 2024-01-17 | — | — | EP | disclosed |
| CN-116963761-A | Small molecule antagonists against relaxin-3/RXFP 3 system | 研究三角协会 | 2023-10-27 | — | — | CN | disclosed |
| WO-2022192126-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RESEARCH TRIANGLE INSTITUTE (US) | 2022-09-15 | — | — | WO | disclosed |