Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998741 | 0.90 | KRAS (0.51) | KRAS | |
| SCHEMBL31691620 | 0.87 | KRAS (0.51) | KRAS | |
| SCHEMBL30922400 | 0.87 | KRAS (0.51) | KRAS | |
| SCHEMBL29936919 | 0.85 | KRAS (0.46) | KRAS | |
| SCHEMBL25240790 | 0.84 | KRAS (0.47) | KRAS | |
| SCHEMBL30539018 | 0.84 | KRAS (0.47) | KRAS | |
| Hydrochloric Acid SCHEMBL30699364 | 0.84 | KRAS (0.46) | KRAS | |
| SCHEMBL29344572 | 0.83 | KRAS (0.54) | KRAS | |
| SCHEMBL25549657 | 0.83 | KRAS (0.47) | KRAS | |
| SCHEMBL25218731 | 0.82 | KRAS (0.53) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024051763-A1 | QUINAZOLINE HETEROCYCLIC DERIVATIVE OF KRAS MUTATION INHIBITOR FOR TREATING CANCER | 深圳福沃药业有限公司 | 2024-03-14 | — | — | WO | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |