Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998397 | 0.87 | KRAS (0.59) | KRAS | |
| SCHEMBL29936989 | 0.81 | KRAS (0.51) | KRAS | |
| SCHEMBL29344335 | 0.78 | KRAS (0.56) | KRAS | |
| SCHEMBL29937296 | 0.77 | KRAS (0.45) | KRAS | |
| SCHEMBL30998802 | 0.75 | KRAS (0.58) | KRAS | |
| SCHEMBL30998657 | 0.75 | KRAS (0.58) | KRAS | |
| SCHEMBL29343995 | 0.74 | KRAS (0.62) | KRAS | |
| SCHEMBL30248982 | 0.74 | KRAS (0.52) | KRAS | |
| SCHEMBL27190964 | 0.74 | KRAS (0.52) | KRAS | |
| SCHEMBL26724979 | 0.74 | KRAS (0.70) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |