Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936949 | 0.79 | KRAS (0.49) | KRAS | |
| SCHEMBL29931969 | 0.74 | KRAS (0.45) | KRAS | |
| SCHEMBL31386553 | 0.73 | KRAS (0.57) | KRASRAF1 | |
| SCHEMBL31089370 | 0.73 | KRAS (0.56) | KRASRAF1 | |
| SCHEMBL31386431 | 0.73 | KRAS (0.58) | KRASRAF1 | |
| SCHEMBL29936938 | 0.72 | KRAS (0.47) | KRAS | |
| SCHEMBL29999467 | 0.72 | KRAS (0.42) | KRAS | |
| SCHEMBL24785204 | 0.72 | KRAS (0.54) | KRASRAF1 | |
| SCHEMBL24785761 | 0.72 | KRAS (0.54) | KRASRAF1 | |
| SCHEMBL24785572 | 0.72 | KRAS (0.54) | KRASRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |