Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.61 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.61 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GGT1 | P19440 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL2993825 | 1.00 | KDM4E (0.61) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL4834297 | 0.96 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL29743139 | 0.96 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL11851702 | 0.96 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL25877 | 0.96 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL25878 | 0.96 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL408904 | 0.93 | KDM4E (0.56) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL19030830 | 0.93 | KDM4E (0.56) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL29743138 | 0.93 | KDM4E (0.56) | KDM4EHSD17B10HPGDALDH1A1PTGS2 | |
| Aspirin SCHEMBL4094492 | 0.91 | KDM4E (0.53) | KDM4EHSD17B10HPGDALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795650-B1 | ADHESIVE COMPOSITION, AND METHOD FOR PREPARING SAME | CJ CHEILJEDANG CORP (KR) | 2026-02-11 | — | — | EP | disclosed |
| US-12410341-B2 | Adhesive composition, and method for preparing same | CJ CHEILJEDANG CORPORATION (KR) | 2025-09-09 | — | — | US | disclosed |
| CN-112334556-B | Adhesive composition, preparation method thereof and adhesive product containing same | CJ第一制糖株式会社 | 2022-12-13 | — | — | CN | disclosed |
| US-20210189180-A1 | ADHESIVE COMPOSITION, AND METHOD FOR PREPARING SAME | CJ CHEILJEDANG CORPORATION (KR) | 2021-06-24 | — | — | US | disclosed |
| EP-3795650-A1 | ADHESIVE COMPOSITION, AND METHOD FOR PREPARING SAME | CJ Cheiljedang Corporation (KR) | 2021-03-24 | — | — | EP | disclosed |
| CN-112334556-A | Adhesive composition and method for preparing the same | CJ第一制糖株式会社 | 2021-02-05 | — | — | CN | disclosed |
| WO-2020046055-A1 | ADHESIVE COMPOSITION, AND METHOD FOR PREPARING SAME | 씨제이제일제당(주) | 2020-03-05 | — | — | WO | disclosed |
| US-8481600-B2 | Formulation of aspirin that is stable and showing minimal hydrolysis for parenteral administration for the treatment of cardiovascular and other disease states | ACADEMIC PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20100173875-A1 | Formulation of aspirin that is stable and showing minimal hydrolysis for parenteral adminstration for the treatment of cardiovascular and other disease states | SOMBERG JOHN CHARIN | 2010-07-08 | — | — | US | disclosed |