Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997883 | 0.91 | NPC1 (0.49) | MAPKAPK2MAPTALDH1A1MAPK1MAP2K1 | |
| SCHEMBL1345394 | 0.88 | MAPKAPK2 (0.52) | MAPKAPK2MAPK1MAP2K1NPC1TRPV1 | |
| SCHEMBL1345952 | 0.79 | MAPT (0.50) | HTR6MAPKAPK2MAPTNPC1RAB9A | |
| SCHEMBL1343706 | 0.79 | MAPKAPK2 (0.44) | MAPKAPK2MAPK1MAP2K1NPC1LMNA | |
| SCHEMBL1345355 | 0.77 | MAPT (0.54) | MAPKAPK2MAPTALDH1A1KDM4E | |
| SCHEMBL1345168 | 0.77 | POLB (0.56) | MAPKAPK2MAPTNPC1KDM4ERAB9A | |
| Acetic Acid SCHEMBL1345951 | 0.77 | MAPT (0.54) | MAPKAPK2MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1345627 | 0.75 | MAPT (0.57) | MAPKAPK2MAPTALDH1A1NPC1KDM4E | |
| SCHEMBL1345624 | 0.74 | MAPT (0.47) | HTR6MAPTALDH1A1TSHRKDM4E | |
| SCHEMBL1346632 | 0.74 | KMT2A (0.56) | MAPTALDH1A1NPC1TRPV1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTR6 4219/4885MAPKAPK2 1/4885MAPT 1938/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTR6 4219/4885MAPKAPK2 1/4885MAPT 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.