Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | CASK | O14936 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19294573 | 1.00 | RET (0.48) | RETABL1PTK6SRCKDR | |
| SCHEMBL23988225 | 0.91 | RET (0.45) | RETABL1PTK6SRCKDR | |
| SCHEMBL29669711 | 0.91 | RET (0.45) | RETABL1PTK6SRCKDR | |
| SCHEMBL29669798 | 0.91 | RET (0.53) | RETABL1PTK6SRCKDR | |
| SCHEMBL23158015 | 0.91 | RET (0.53) | RETABL1PTK6SRCKDR | |
| SCHEMBL25678097 | 0.91 | RET (0.56) | RETABL1PTK6SRCKDR | |
| SCHEMBL17595914 | 0.90 | RET (0.51) | RETABL1PTK6SRCKDR | |
| SCHEMBL23157800 | 0.86 | RET (0.55) | RETABL1PTK6SRCKDR | |
| SCHEMBL29669709 | 0.86 | RET (0.55) | RETABL1PTK6SRCKDR | |
| SCHEMBL23251826 | 0.85 | RET (0.42) | RETABL1PTK6SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099597-A1 | mTORC1 INHIBITORS | THE REGENTS OF THE UNIV OF CLAFORNIA (US) | 2025-03-27 | — | — | US | disclosed |
| US-12097262-B2 | mTORC1 inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-09-24 | — | — | US | disclosed |
| US-20240066134-A1 | mTORC1 INHIBITORS | UNIV CALIFORNIA (US) | 2024-02-29 | — | — | US | disclosed |
| US-11452780-B2 | Mtorc1 inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12097262-B2 | mTORC1 inhibitors | MTOR, RPTOR, RICTOR | RET 2053/4885ABL1 1496/4885PTK6 1601/4885 |
| US-20240066134-A1 | mTORC1 INHIBITORS | MTOR, RPTOR, RICTOR | RET 2053/4885ABL1 1496/4885PTK6 1601/4885 |
| US-20250099597-A1 | mTORC1 INHIBITORS | MTOR, RPTOR, RICTOR | RET 2053/4885ABL1 1496/4885PTK6 1601/4885 |
| US-11452780-B2 | Mtorc1 inhibitors | MTOR, RPTOR, RICTOR | RET 2053/4885ABL1 1496/4885PTK6 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.