Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 19/20 | 0.60 |
| ▸ | GSK3B | P49841 | 19/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205109 | 1.00 | GSK3A (0.60) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20205116 | 0.89 | GSK3A (0.65) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20189422 | 0.87 | GSK3A (0.77) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL29939479 | 0.87 | GSK3A (0.77) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL29939389 | 0.86 | GSK3A (0.57) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20204918 | 0.86 | GSK3A (0.57) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20189895 | 0.84 | GSK3A (0.64) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20189856 | 0.83 | GSK3A (0.58) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL29939095 | 0.82 | GSK3A (0.64) | GSK3AGSK3BPIM1JAK2CDK2 | |
| SCHEMBL20190090 | 0.82 | GSK3A (0.64) | GSK3AGSK3BPIM1JAK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |