Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.57 |
| ▸ | KDR | P35968 | 9/20 | 0.57 |
| ▸ | BRAF | P15056 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27082274 | 1.00 | ABL1 (0.58) | ABL1KITRETFGFR1KDR | |
| SCHEMBL27082321 | 0.88 | BRAF (0.59) | ABL1KITRETFGFR1KDR | |
| SCHEMBL29940076 | 0.88 | BRAF (0.59) | ABL1KITRETFGFR1KDR | |
| SCHEMBL27083161 | 0.84 | BRAF (0.68) | ABL1KITRETBRAFEGFR | |
| SCHEMBL27083160 | 0.84 | BRAF (0.68) | ABL1KITBRAFEGFR | |
| SCHEMBL27081580 | 0.84 | BRAF (0.55) | ABL1KITRETBRAFEGFR | |
| SCHEMBL29967823 | 0.84 | BRAF (0.55) | ABL1KITRETBRAFEGFR | |
| SCHEMBL27083097 | 0.83 | EGFR (0.68) | ABL1FGFR1BRAFEGFR | |
| SCHEMBL27082299 | 0.83 | BRAF (0.59) | ABL1KITBRAFEGFR | |
| SCHEMBL27082370 | 0.83 | KIT (0.63) | ABL1KITRETBRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313292-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200576-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |