Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 6/20 | 0.67 |
| ▸ | DDR1 | Q08345 | 8/20 | 0.63 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.63 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.63 |
| ▸ | ABL1 | P00519 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.61 |
| ▸ | LDLR | P01130 | 1/20 | 0.61 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 3/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | CDK11B | P21127 | 1/20 | 0.58 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.58 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081838 | 1.00 | NR2E1 (0.67) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27081940 | 0.89 | KDM4E (0.63) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27289164 | 0.88 | DDR1 (0.58) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL13659898 | 0.83 | NR2E1 (0.77) | NR2E1ABL1KITPDGFRBEPHB2 | |
| SCHEMBL20503056 | 0.83 | NR2E1 (0.84) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27081728 | 0.82 | NR2E1 (0.65) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL31729797 | 0.82 | NR2E1 (0.82) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL31729830 | 0.81 | NR2E1 (0.74) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL31729819 | 0.81 | NR2E1 (0.81) | NR2E1DDR1DDR2ABL1KIT | |
| SCHEMBL29561954 | 0.81 | NR2E1 (1.00) | NR2E1ABL1KITPDGFRBEPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313292-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| EP-4313972-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| CN-117062812-A | Indoline derivatives as DDR inhibitors | 奇斯药制品公司 | 2023-11-14 | — | — | CN | disclosed |
| WO-2022200577-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |
| WO-2022200576-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |