Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.67 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.64 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.64 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087613 | 0.90 | ALK (0.79) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL30786730 | 0.90 | ALK (0.63) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL28913340 | 0.90 | ALK (0.63) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL30760748 | 0.89 | ALK (0.70) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL29940244 | 0.88 | ALK (0.80) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL27087524 | 0.88 | ALK (0.80) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL27087616 | 0.86 | ALK (0.52) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL29940661 | 0.85 | ALK (0.76) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL27087542 | 0.85 | ALK (0.76) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL27087610 | 0.85 | ALK (0.68) | ALKEML4SRPK2SRPK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4321514-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | CGeneTech (Suzhou, China) Co., Ltd. (CN) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022237813-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-17 | — | — | WO | disclosed |
| CN-115340523-A | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-15 | — | — | CN | disclosed |