Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16680447 | 1.00 | MAPKAPK2 (0.39) | MAPKAPK2ATRMAPK1HTTKMT2A | |
| SCHEMBL16679950 | 0.91 | MAPK1 (0.36) | MAPKAPK2ATRMAPK1HTTKMT2A | |
| SCHEMBL16679951 | 0.91 | MAPK1 (0.36) | MAPKAPK2ATRMAPK1HTTKMT2A | |
| SCHEMBL19053651 | 0.91 | MAPKAPK2 (0.35) | MAPKAPK2ATRMAPK1 | |
| SCHEMBL17187742 | 0.91 | ATR (0.47) | MAPKAPK2ATRMAPK1ADORA2AADORA1 | |
| SCHEMBL16679534 | 0.88 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL16679616 | 0.88 | HRH4 (0.46) | MAPKAPK2ATRKMT2AUSP7 | |
| SCHEMBL29419391 | 0.88 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL16680538 | 0.87 | MAPK1 (0.41) | MAPKAPK2ATRMAPK1 | |
| SCHEMBL16680537 | 0.87 | MAPK1 (0.41) | MAPKAPK2ATRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |