Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 8/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.64 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.47 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21430880 | 1.00 | FGFR2 (0.64) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL21430977 | 0.90 | FGFR2 (0.51) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL29940530 | 0.88 | FGFR1 (0.68) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL21430881 | 0.88 | FGFR1 (0.68) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL21430739 | 0.87 | FGFR2 (0.75) | FGFR2FGFR1FGFR3FGFR4AURKB | |
| SCHEMBL29941049 | 0.87 | FGFR2 (0.75) | FGFR2FGFR1FGFR3FGFR4AURKB | |
| Morpholine SCHEMBL28492598 | 0.86 | FGFR2 (0.67) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL21408448 | 0.85 | FGFR4 (0.83) | FGFR2FGFR1FGFR3FGFR4AURKB | |
| SCHEMBL63282 | 0.85 | FGFR1 (0.61) | FGFR2FGFR1FGFR3FGFR4KDR | |
| SCHEMBL21430878 | 0.84 | FGFR4 (0.71) | FGFR2FGFR1FGFR3FGFR4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936470-B | Amidopyrazoles useful as irreversible FGFR inhibitors | 上海奕拓医药科技有限责任公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-110317173-B | Amidopyrazoles useful as irreversible FGFR inhibitors | 上海奕拓医药科技有限责任公司 | 2022-10-11 | — | — | CN | disclosed |