Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.53 |
| ▸ | SRPK1 | Q96SB4 | 4/20 | 0.47 |
| ▸ | SRPK2 | P78362 | 3/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087513 | 1.00 | ALK (0.53) | ALKSRPK1SRPK2DYRK3CLK1 | |
| SCHEMBL7812557 | 0.89 | SRPK1 (0.47) | ALKSRPK1SRPK2DYRK3CLK1 | |
| SCHEMBL27087556 | 0.88 | ALK (0.56) | ALK | |
| SCHEMBL29940536 | 0.88 | ALK (0.56) | ALK | |
| SCHEMBL898305 | 0.86 | SRPK1 (0.65) | ALKSRPK1SRPK2DYRK3CLK1 | |
| SCHEMBL29940408 | 0.85 | ALK (0.53) | ALK | |
| SCHEMBL27087583 | 0.85 | ALK (0.53) | ALK | |
| SCHEMBL27087579 | 0.85 | ALK (0.64) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL20366631 | 0.85 | SRPK1 (0.44) | ALKSRPK1SRPK2DYRK3CLK1 | |
| SCHEMBL7805478 | 0.81 | ALK (0.43) | ALKSRPK1SRPK2DYRK3CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4321514-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | CGeneTech (Suzhou, China) Co., Ltd. (CN) | 2024-02-14 | — | — | EP | disclosed |
| CN-115340523-B | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2022237813-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-17 | — | — | WO | disclosed |
| CN-115340523-A | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-15 | — | — | CN | disclosed |