Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 8/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.76 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.76 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | MARK3 | P27448 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.53 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.53 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.53 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21431009 | 1.00 | FGFR2 (0.76) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL23060171 | 0.89 | FGFR1 (0.77) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL21430886 | 0.87 | FGFR4 (1.00) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL63319 | 0.86 | FGFR2 (0.72) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL23409073 | 0.86 | FGFR2 (0.72) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL23409129 | 0.85 | FGFR2 (0.71) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL23409135 | 0.85 | FGFR2 (0.71) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL25068969 | 0.84 | FGFR2 (0.70) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL24594166 | 0.82 | FGFR2 (0.76) | FGFR2FGFR1FGFR4FGFR3NTRK1 | |
| SCHEMBL28410479 | 0.82 | FGFR2 (0.76) | FGFR2FGFR1FGFR4FGFR3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936470-B | Amidopyrazoles useful as irreversible FGFR inhibitors | 上海奕拓医药科技有限责任公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-110317173-B | Amidopyrazoles useful as irreversible FGFR inhibitors | 上海奕拓医药科技有限责任公司 | 2022-10-11 | — | — | CN | disclosed |