Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779819 | 0.82 | HTT (0.64) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8859357 | 0.79 | HTT (0.74) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1777959 | 0.77 | HTT (0.57) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1777962 | 0.77 | HTT (0.57) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6966371 | 0.76 | SMN1; SMN2 (1.00) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2453964 | 0.75 | SMN1; SMN2 (0.66) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| Water SCHEMBL11652814 | 0.74 | SMN1; SMN2 (0.96) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11330176 | 0.72 | SMN1; SMN2 (0.61) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31755975 | 0.72 | SMN1; SMN2 (0.61) | HTTALOX15SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12770947 | 0.72 | MEN1 (0.65) | HTTALOX15SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022204377-A1 | NOVEL CHEMICAL COMBINATIONS AND METHODS OF USE THEREOF, TOWARDS DIFFERENTIATION OF HUMAN PROGENITOR CELLS INTO FUNCTIONAL β CELLS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2022-09-29 | — | — | WO | disclosed |