Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF1 | P36956 | 15/20 | 0.89 |
| ▸ | NR1H2 | P55055 | 12/20 | 0.89 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.89 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27245361 | 1.00 | SREBF1 (0.89) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL27030539 | 0.94 | SREBF1 (1.00) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL27030601 | 0.93 | SREBF1 (0.89) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL27030630 | 0.90 | SREBF1 (0.72) | SREBF1NR1H2NR1H3NPC1RAB9A | |
| SCHEMBL27245358 | 0.89 | SREBF1 (0.85) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL27245333 | 0.88 | SREBF1 (0.80) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL29944868 | 0.88 | SREBF1 (0.80) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL29944871 | 0.87 | SREBF1 (0.79) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL27245334 | 0.87 | SREBF1 (0.79) | SREBF1NR1H2NR1H3NPC1MAPT | |
| SCHEMBL29944856 | 0.86 | NR1H2 (1.00) | SREBF1NR1H2NR1H3NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308554-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | The Board of Trustees of the University of Illinois (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197658-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-09-22 | — | — | WO | disclosed |