SCHEMBL29945528

SCHEMBL29945528

O=C(NNc1cccc(Br)c1)c1ccccn1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 4/20 0.57
MITF O75030 1/20 0.56
GRM4 Q14833 4/20 0.54
HDAC6 Q9UBN7 1/20 0.54
KDR P35968 4/20 0.52
KCNK3 O14649 1/20 0.52
KCNK9 Q9NPC2 1/20 0.52
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
AGTR1 P30556 1/20 0.50
OPRK1 P41145 1/20 0.50
KDM5A P29375 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
PKM P14618 1/20 0.48
GFER P55789 1/20 0.48
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
HTT P42858 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28871753 1.00 TLR7 (0.57) TLR7MITFGRM4HDAC6KDR
SCHEMBL28904211 0.87 GRM4 (0.70) GRM4HDAC6KDRKCNK3KCNK9
SCHEMBL28871718 0.84 GRM4 (0.76) TLR7GRM4HDAC6KDRKCNK3
SCHEMBL28871740 0.84 TLR7 (0.70) TLR7GRM4NPC1RAB9AOPRK1
SCHEMBL28871817 0.83 KDM5A (0.63) TLR7GRM4HDAC6KDRKCNK3
SCHEMBL28871825 0.83 GAA (0.58) TLR7GRM4HDAC6KDRKCNK3
SCHEMBL28957418 0.83 TLR7 (0.57) TLR7GRM4HDAC6KDRKCNK3
SCHEMBL28639316 0.81 TLR7 (0.71) TLR7MITFKCNK3KCNK9NPC1
SCHEMBL31006474 0.80 GRM4 (0.78) GRM4HDAC6KDRKCNK3KCNK9
SCHEMBL31006491 0.80 GRM4 (0.78) TLR7MITFGRM4NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108978-B Pyridine formylhydrazine plant antifungal medicine 西北农林科技大学 2024-05-24 CN disclosed
CN-115108978-A Pyridine formyl hydrazine plant antifungal drugs 西北农林科技大学 2022-09-27 CN disclosed