Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 11/20 | 1.00 |
| ▸ | ORAI1 | Q96D31 | 11/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.51 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.51 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26628329 | 1.00 | STIM1 (1.00) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL26628325 | 0.93 | STIM1 (1.00) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL29946160 | 0.93 | STIM1 (1.00) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL29946111 | 0.91 | STIM1 (0.84) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL26628276 | 0.91 | STIM1 (0.84) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL1429965 | 0.91 | STIM1 (0.83) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL181689 | 0.87 | STIM1 (0.85) | STIM1ORAI1CYP1B1LDHAKEAP1 | |
| SCHEMBL26628304 | 0.87 | STIM1 (0.76) | STIM1ORAI1LDHAKEAP1NFE2L2 | |
| SCHEMBL29946192 | 0.87 | STIM1 (0.76) | STIM1ORAI1LDHAKEAP1NFE2L2 | |
| SCHEMBL10195868 | 0.86 | STIM1 (0.83) | STIM1ORAI1CYP1B1LDHAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4106871-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" (IT) | 2022-12-28 | — | — | EP | claimed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | claimed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | ORAI1, SARAF, STIM1 | STIM1 3/4885ORAI1 1/4885CYP1B1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.