Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.66 |
| ▸ | IKBKB | O14920 | 9/20 | 0.53 |
| ▸ | CHUK | O15111 | 9/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991561 | 0.94 | MAP3K5 (0.73) | MAP3K5IKBKBCHUKROCK1P2RY14 | |
| Trifluoroacetic Acid SCHEMBL2985548 | 0.93 | IKBKB (0.62) | MAP3K5IKBKBCHUKROCK1P2RY14 | |
| SCHEMBL2997188 | 0.88 | IKBKB (0.68) | MAP3K5IKBKBCHUKROCK1P2RY14 | |
| Trifluoroacetic Acid SCHEMBL2988572 | 0.87 | MAP3K5 (0.51) | MAP3K5IKBKBCHUKCITCAPN1 | |
| SCHEMBL2985551 | 0.85 | MAP3K5 (0.53) | MAP3K5IKBKBCHUKROCK1P2RY14 | |
| Trifluoroacetic Acid SCHEMBL3414334 | 0.83 | IKBKB (0.78) | MAP3K5IKBKBCHUKROCK1CIT | |
| SCHEMBL2984785 | 0.82 | IKBKB (0.52) | MAP3K5IKBKBCHUKCITCYP2C9 | |
| SCHEMBL2981752 | 0.81 | MAP3K5 (0.55) | MAP3K5IKBKBCHUKROCK1CIT | |
| Trifluoroacetic Acid SCHEMBL2991581 | 0.81 | IKBKB (0.61) | MAP3K5IKBKBCHUKROCK1CIT | |
| SCHEMBL2984098 | 0.81 | MAP3K5 (0.54) | MAP3K5IKBKBCHUKCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179139-A1 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | BAMBOROUGH PAUL | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179139-A1 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | NFKBIA, PACSIN2, MAP3K2 | MAP3K5 7/4885IKBKB 11/4885CHUK 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.