Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206594 | 0.80 | HTT (0.52) | HTTKMT2ASCDGRM5MAPT | |
| SCHEMBL23043784 | 0.78 | HTT (0.54) | HTTKMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL1274938 | 0.78 | HTT (0.73) | HTTKMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL20524657 | 0.78 | GPR6 (0.50) | HTTKMT2ASCDMAPTALDH1A1 | |
| SCHEMBL8259200 | 0.78 | MAPT (0.60) | HTTKMT2AMAPTALDH1A1LMNA | |
| SCHEMBL30784064 | 0.78 | MAPT (0.60) | HTTKMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL3436179 | 0.78 | KMT2A (0.56) | HTTKMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL11507421 | 0.78 | HTT (0.56) | HTTKMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL3704174 | 0.78 | MAPT (0.65) | KMT2AMAPTALDH1A1TDP1NAMPT | |
| SCHEMBL29788336 | 0.77 | TDP1 (0.69) | HTTKMT2AGRM5MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337206-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | Libra Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240992-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |