Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527992 | 1.00 | PARP1 (0.50) | PARP1NR1H2NR1H3CA1CA2 | |
| SCHEMBL337351 | 0.89 | PARP1 (0.54) | PARP1 | |
| SCHEMBL336578 | 0.89 | PARP1 (0.54) | PARP1 | |
| SCHEMBL336577 | 0.89 | PARP1 (0.54) | PARP1 | |
| SCHEMBL2876651 | 0.87 | PARP1 (0.48) | PARP1NR1H2NR1H3CA1CA2 | |
| SCHEMBL2876652 | 0.87 | PARP1 (0.48) | PARP1NR1H2NR1H3CA1CA2 | |
| SCHEMBL30879748 | 0.85 | PARP1 (0.49) | PARP1NR1H2NR1H3CA1CA2 | |
| SCHEMBL1990452 | 0.83 | PARP1 (0.54) | PARP1NR1H2 | |
| SCHEMBL1990451 | 0.83 | PARP1 (0.54) | PARP1NR1H2 | |
| SCHEMBL1994122 | 0.83 | PARP1 (0.54) | PARP1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |