Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12280477 | 1.00 | USP30 (0.47) | USP30ABHD6ROCK1ESR2DDB1 | |
| SCHEMBL2589826 | 0.83 | ROCK1 (0.48) | USP30ABHD6ROCK1ESR2DDB1 | |
| SCHEMBL18056973 | 0.83 | USP30 (0.42) | USP30ROCK1ESR2DDB1CRBN | |
| SCHEMBL15779506 | 0.82 | USP30 (0.47) | USP30ABHD6ROCK1ESR2DDB1 | |
| SCHEMBL2970830 | 0.82 | USP30 (0.44) | USP30ROCK1ESR2DDB1CRBN | |
| SCHEMBL12279252 | 0.81 | USP30 (0.41) | USP30ROCK1ESR2DDB1CRBN | |
| SCHEMBL20425868 | 0.80 | ROCK1 (0.46) | ABHD6ROCK1ESR2NAMPTKDM4E | |
| SCHEMBL2515678 | 0.80 | NR1H2 (0.61) | USP30ABHD6ROCK1ESR2DDB1 | |
| SCHEMBL29964782 | 0.80 | NR1H2 (0.61) | USP30ABHD6ROCK1ESR2DDB1 | |
| SCHEMBL29676899 | 0.80 | ESR2 (0.62) | USP30ABHD6ROCK1ESR2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337207-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | Opna Bio SA (CH) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240966-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | OPNA IMMUNO-ONCOLOGY SA (CH) | 2022-11-17 | — | — | WO | disclosed |