Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.41 |
| ▸ | EGFR | P00533 | 8/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886780 | 0.86 | ALK (0.54) | ALKEGFRFLT3ROS1LRRK2 | |
| SCHEMBL886034 | 0.76 | ALK (0.59) | ALKEGFRFLT3ROS1LRRK2 | |
| SCHEMBL16966105 | 0.75 | ALK (0.45) | ALKEGFRROS1 | |
| SCHEMBL2062455 | 0.74 | ALK (0.61) | ALKFLT3 | |
| SCHEMBL3007550 | 0.71 | ALK (0.62) | ALKFLT3 | |
| SCHEMBL886077 | 0.70 | AXL (0.67) | ALK | |
| SCHEMBL2063059 | 0.67 | ALK (0.66) | ALK | |
| SCHEMBL2062527 | 0.67 | ALK (0.64) | ALKROS1 | |
| SCHEMBL886301 | 0.66 | ALK (0.56) | ALKEGFRFLT3ROS1LRRK2 | |
| SCHEMBL16966154 | 0.66 | ALK (0.44) | ALKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |