Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276837 | 0.83 | MAP4K4 (0.49) | CHEK2FYNMKNK1MKNK2AXL | |
| SCHEMBL29955261 | 0.83 | MAP4K4 (0.49) | CHEK2FYNMKNK1MKNK2AXL | |
| SCHEMBL18615838 | 0.82 | MAP4K4 (0.51) | CHEK2FYNMKNK1MKNK2 | |
| SCHEMBL29954696 | 0.82 | ERN1 (0.51) | ERN1CHEK2FYNEGFRPDGFRB | |
| SCHEMBL12833995 | 0.81 | ERN1 (0.66) | ERN1CHEK2MKNK1MKNK2CYP2A6 | |
| SCHEMBL29066279 | 0.81 | ERN1 (0.61) | ERN1MKNK1MKNK2CYP2A6CYP3A4 | |
| SCHEMBL5782678 | 0.79 | ERN1 (0.61) | ERN1MKNK1MKNK2CYP2A6CYP3A4 | |
| SCHEMBL712179 | 0.78 | FYN (0.58) | CHEK2FYNMKNK1MKNK2MEN1 | |
| SCHEMBL2556015 | 0.78 | CHEK2 (0.52) | CHEK2FYNMEN1PDGFRBPDGFRA | |
| SCHEMBL16835804 | 0.76 | FYN (0.52) | ERN1CHEK2FYNMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |