Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13280504 | 1.00 | BACE1 (0.41) | BACE1NR1H2CA12CA9CCR2 | |
| SCHEMBL13515301 | 0.85 | NR1H2 (0.40) | NR1H2CA12CA9NR1H3TGFBR1 | |
| SCHEMBL2873473 | 0.84 | NR1H2 (0.40) | NR1H2CA12CA9NR1H3 | |
| SCHEMBL4242068 | 0.84 | NR1H2 (0.40) | BACE1NR1H2CA12CA9CCR2 | |
| SCHEMBL15431762 | 0.83 | BACE1 (0.43) | BACE1NR1H2CA12CA9CCR2 | |
| SCHEMBL759123 | 0.83 | NR1H2 (0.40) | BACE1NR1H2CA12CA9NR1H3 | |
| SCHEMBL30016078 | 0.83 | NR1H2 (0.40) | BACE1NR1H2CA12CA9NR1H3 | |
| SCHEMBL18567358 | 0.82 | BACE1 (0.44) | BACE1NR1H2CA12CA9CCR2 | |
| SCHEMBL2926879 | 0.80 | NR1H2 (0.40) | NR1H2CA12CA9CCR2NR1H3 | |
| SCHEMBL1550715 | 0.78 | PDE4B (0.34) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |