Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578894 | 1.00 | DHODH (0.56) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23590210 | 0.89 | DHODH (0.58) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23590331 | 0.89 | DHODH (0.62) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23590082 | 0.88 | DHODH (0.69) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL25118724 | 0.86 | DHODH (0.59) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL29997396 | 0.85 | DHODH (0.59) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23579626 | 0.85 | DHODH (0.59) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23590127 | 0.85 | DHODH (0.55) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23590320 | 0.85 | DHODH (0.55) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23579617 | 0.85 | DHODH (0.55) | DHODHMEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081512-A1 | COMPOSITIONS FOR USE FOR THE INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |