Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.90 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CHKA | P35790 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15687976 | 1.00 | NR1H2 (0.90) | NR1H2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL29493475 | 0.95 | NR1H2 (1.00) | NR1H2POLBKDM4EALDH1A1LMNA | |
| SCHEMBL273351 | 0.95 | NR1H2 (1.00) | NR1H2POLBKDM4EALDH1A1LMNA | |
| SCHEMBL4933173 | 0.90 | NR1H2 (0.76) | NR1H2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL24566522 | 0.88 | NR1H2 (0.73) | NR1H2POLBKDM4EALDH1A1ACHE | |
| SCHEMBL545052 | 0.87 | NR1H2 (0.76) | NR1H2POLBKDM4EALDH1A1KMT2A | |
| SCHEMBL3166705 | 0.86 | NR1H2 (0.74) | NR1H2POLBKDM4EALDH1A1KMT2A | |
| SCHEMBL29998843 | 0.86 | NR1H2 (0.74) | NR1H2POLBKDM4EALDH1A1KMT2A | |
| SCHEMBL15006475 | 0.85 | POLB (0.69) | NR1H2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL7808220 | 0.85 | POLB (0.69) | NR1H2POLBKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226182-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-27 | — | — | WO | disclosed |