Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 10/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292670 | 0.94 | CYP2C9 (1.00) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF | |
| SCHEMBL291570 | 0.92 | CYP2C9 (1.00) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF | |
| SCHEMBL299314 | 0.91 | CYP2C9 (0.82) | CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL299537 | 0.89 | CYP3A4 (0.87) | CYP2C9CYP3A4CYP2C19CYP2D6KDM4E | |
| SCHEMBL298729 | 0.89 | CYP3A4 (1.00) | CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL294562 | 0.89 | CYP2C9 (0.84) | CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL295492 | 0.88 | CYP2C9 (0.84) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF | |
| SCHEMBL299237 | 0.88 | CYP2C9 (0.76) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF | |
| SCHEMBL297958 | 0.87 | CYP3A4 (0.79) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF | |
| SCHEMBL298852 | 0.87 | CYP2C9 (1.00) | CYP2C9CYP3A4CYP2C19CYP2D6BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | CYP2C9 2176/4885CYP3A4 3611/4885CYP2C19 2730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.