Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828145 | 1.00 | KRAS (0.50) | KRAS | |
| SCHEMBL30002547 | 0.95 | KRAS (0.50) | KRAS | |
| SCHEMBL29827960 | 0.94 | KRAS (0.47) | KRAS | |
| SCHEMBL28676690 | 0.93 | KRAS (0.44) | KRAS | |
| SCHEMBL29828315 | 0.93 | KRAS (0.44) | KRAS | |
| SCHEMBL31220148 | 0.92 | KRAS (0.48) | KRAS | |
| SCHEMBL25829779 | 0.90 | KRAS (0.42) | KRAS | |
| SCHEMBL29828426 | 0.90 | KRAS (0.44) | KRAS | |
| SCHEMBL29828387 | 0.89 | KRAS (0.41) | KRAS | |
| SCHEMBL30001905 | 0.89 | KRAS (0.52) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116113416-B | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-116848111-A | KRAS inhibitor key intermediate and preparation method thereof | 浙江海正药业股份有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116113416-A | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-115124533-A | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| WO-2022198904-A1 | KEY INTERMEDIATE OF KRAS INHIBITOR AND PREPARATION METHOD THEREFOR | 浙江海正药业股份有限公司 | 2022-09-29 | — | — | WO | disclosed |
| WO-2022199170-A1 | TETRACYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 浙江海正药业股份有限公司 | 2022-09-29 | — | — | WO | disclosed |